Data/hora: 13/06/2024 23:58:48

Provedor de dados: | 56
País: | Brazil
Título: | Substance P immunoreactivity in the lumbar spinal cord of the turtle Trachemys dorbigni following peripheral nerve injury
Autores: | Partata,W.A.; Krepsky,A.M.R.; Xavier,L.L.; Marques,M.; Achaval,M.
Data: | 2003-04-01
Ano: | 2003
Palavras-chave: | Substance P immunoreactivity; Axonal injury; Spinal cord; Turtle; Trachemys dorbigni.
Resumo: | Immunoreactive substance P was investigated in turtle lumbar spinal cord after sciatic nerve transection. In control animals immunoreactive fibers were densest in synaptic field Ia, where the longest axons invaded synaptic field III. Positive neuronal bodies were identified in the lateral column of the dorsal horn and substance P immunoreactive varicosities were observed in the ventral horn, in close relationship with presumed motoneurons. Other varicosities appeared in the lateral and anterior funiculi. After axotomy, substance P immunoreactive fibers were reduced slightly on the side of the lesion, which was located in long fibers that invaded synaptic field III and in the varicosities of the lateral and anterior funiculus. The changes were observed at 7 days after axonal injury and persisted at 15, 30, 60 and 90 days after the lesion. These findings show that turtles should be considered as a model to study the role of substance P in peripheral axonal injury, since the distribution and temporal changes of substance P were similar to those found in mammals.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000400015
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2003000400015
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.36 n.4 2003
Fonte: | info:eu-repo/semantics/openAccess