Data/hora: 04/06/2024 02:22:24

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation
Autores: | Dai,F.; Zhang,F.; Sun,D.; Zhang,Z.H.; Dong,S.W.; Xu,J.Z.
Data: | 2015-07-01
Ano: | 2015
Palavras-chave: | CTLA4; Mesenchymal stem cells; Immunomodulatory; Bone tissue engineering.
Resumo: | Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic differentiation was inhibited in the presence of the activated immune response and that overexpression of CTLA4 in allo-MSCs suppressed the immune response and promoted osteogenic differentiation. Our results support the application of CTLA4-overexpressing allo-MSCs in bone tissue engineering.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700629
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20154209
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.48 n.7 2015
Fonte: | info:eu-repo/semantics/openAccess