Data/hora: 08/06/2024 04:33:51

Provedor de dados: | 56
País: | Brazil
Título: | Novel methods for the encapsulation of meglumine antimoniate into liposomes
Autores: | Frézard,F.; Michalick,M.S.M.; Soares,C.F.; Demicheli,C.
Data: | 2000-07-01
Ano: | 2000
Palavras-chave: | Liposomes; Glucantime; Meglumine antimoniate; Leishmaniasis; Encapsulation.
Resumo: | The antimonial drug, meglumine antimoniate, was successfully encapsulated in dehydration-rehydration vesicles and in freeze-dried empty liposomes (FDELs). High encapsulation efficiencies (from 28 to 58%) and low weight ratios of lipids to encapsulated antimony (from 1:0.15 to 1:0.3) were achieved. These formulations, contrary to those obtained by conventional methods, can be stored as intermediate lyophilized forms and reconstituted just before use. The efficacy of FDEL-encapsulated meglumine antimoniate was evaluated in hamsters experimentally infected with Leishmania chagasi. A significant reduction of liver parasite burdens was observed in animals treated with this preparation, when compared to control animals treated with empty liposomes. In contrast, free meglumine antimoniate was found to be inefficient when administered at a comparable dose of antimony. This novel liposome-based meglumine antimoniate formulation appears to be promising as a pharmaceutical product for the treatment of visceral leishmaniasis.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700016
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000000700016
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.7 2000
Fonte: | info:eu-repo/semantics/openAccess