Data/hora: 09/06/2024 04:23:38

Provedor de dados: | 56
País: | Brazil
Título: | Inhibition of Mayaro virus replication by prostaglandin A1 and B2 in Vero cells
Autores: | Ishimaru,D.; Marcicano,F.G.P.; Rebello,M.A.
Data: | 1998-09-01
Ano: | 1998
Palavras-chave: | Prostaglandins; Mayaro virus; Vero cells; Protein synthesis.
Resumo: | The effect of prostaglandins (PGA1 and PGB2) on the replication of Mayaro virus was studied in Vero cells. PGA1 and PGB2 antiviral activity was found to be dose-dependent. However, while 10 µg/ml PGB2 inhibited virus yield by 60%, at the same dose PGA1 suppressed virus replication by more than 90%. SDS-PAGE analysis of [35S]-methionine-labelled proteins showed that PGA1 did not alter cellular protein synthesis. In infected cells, PGA1 slightly inhibited the synthesis of protein C, while drastically inhibiting the synthesis of glycoproteins E1 and E2.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900003
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000900003
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.9 1998
Fonte: | info:eu-repo/semantics/openAccess