Data/hora: 17/06/2024 11:54:00

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Overexpression of Fc receptor-like 1 associated with B-cell activation during hepatitis B virus infection	
Autores: 	Wang,Ke; Pei,Hao; Huang,Biao; Yang,Run-Lin; Wu,Hang-Yuan; Zhu,Xue; Zhu,Lan.	
Data: 	2012-12-01	
Ano: 	2012	
Palavras-chave: 	Hepatitis B virus; B-cell activation; Fc receptor-like 1; Gene expression.	
Resumo: 	The role of B cells in the pathogenesis of hepatitis B virus (HBV) infection has not been explored in depth. In the present study, the activation status of B cells from peripheral blood of healthy controls (N = 20) and patients with acute hepatitis B (AHB, N = 15) or chronic hepatitis B (CHB, N = 30) was evaluated by measuring the expression levels of B-cell activation markers CD69 and CD86, using quantitative real-time PCR and flow cytometry. Moreover, the potential mechanism underlying B-cell activation during HBV infection was further investigated by analyzing the expression profile of FCRL1, an intrinsic activation molecule of B cells. An elevation in the levels of B-cell activation markers including CD69 and CD86 was observed in the AHB patients (44.31 ± 9.27, 27.64 ± 9.26%) compared to CHB patients (30.35 ± 11.27, 18.41 ± 6.56%, P &lt; 0.05), which was still higher than healthy controls (12.23 ± 7.84, 8.22 ± 3.43%, P &lt; 0.05). Furthermore, the expression of FCRL1 was found to be similar to B-cell activation markers, which was highest in AHB patients (70.15 ± 17.11%), lowest in healthy donors (36.32 ± 9.98%, P &lt; 0.05) and half-way between these levels in patients with CHB (55.17 ± 12.03%, P &lt; 0.05). The results were positively associated with aberrant B-cell activation. These data suggest that B cells can play a role in HBV infection, and therefore more effort should be devoted to exploring their functions.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200002	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2012007500130	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.45 n.12 2012	
Fonte: 	info:eu-repo/semantics/openAccess