Data/hora: 29/05/2024 03:32:56

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Cerebrospinal fluid-contacting nucleus mediates nociception via release of fractalkine
Autores: | Zhou,Q.Q.; Chen,S.S.; Zhang,Q.Q.; Liu,P.F.; Fang,H.Z.; Yang,Y.; Zhang,L.C.
Data: | 2017-01-01
Ano: | 2017
Palavras-chave: | Cerebrospinal fluid-contacting nucleus; FKN; Microglia; Neuropathic pain; Chronic constriction injury.
Resumo: | Increasing evidence suggests that the cerebrospinal ﬂuid-contacting nucleus (CSF-contacting nucleus) mediates the transduction and regulation of pain signals. However, the precise molecular mechanisms remain unclear. Studies show that release of fractalkine (FKN) from neurons plays a critical role in nerve injury-related pain. We tested the hypothesis that release of FKN from the CSF-contacting nucleus regulates neuropathic pain, in a chronic constriction injury rat model. The results show that FKN is expressed by neurons, via expression of its only receptor CX3CR1 in the microglia. The levels of soluble FKN (sFKN) were markedly upregulated along with the increase in FKN mRNA level in rats subjected to chronic constriction injury. In addition, injection of FKN-neutralizing antibody into the lateral ventricle alleviated neuropathic pain-related behavior followed by reduction in microglial activation in the CSF-contacting nucleus. The results indicate that inhibition of FKN release by the CSF-contacting nucleus may ameliorate neuropathic pain clinically.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900610
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20176275
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.50 n.9 2017
Fonte: | info:eu-repo/semantics/openAccess