Data/hora: 10/06/2024 14:58:35

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Restoration of the rabbit corneal surface after total epithelial debridement and complete limbal excision
Autores: | Faria-e-Sousa,S.J.; Haddad,A.
Data: | 2012-05-01
Ano: | 2012
Palavras-chave: | Corneal epithelium; Conjunctiva; Stem cells; Epithelium transformation.
Resumo: | How is the corneal epithelium restored when all of it plus the limbus have been eliminated? This investigation explored the possibility that this may be achieved through the conjunctival epithelium. The corneal epithelium of the right eye of 12 rabbits (Oryctolagus cuniculus) was totally scraped followed by surgical excision of the limbus plus 1.0-1.5 mm of the adjacent conjunctiva. Antibiotics and corticosteroids were applied for 1 week after surgery. Histological and immunohistochemical techniques were used to monitor the events taking place on the eye surface 2 weeks and 1, 3 and 6 months thereafter. Initially, the corneal surface was covered by conjunctival-like epithelium. After 1 month and more prominently at 3 and 6 months an epithelium displaying the morphological features of the cornea and reacting with the AE5 antibody was covering the central region. It is likely that the corneal epithelium originated from undifferentiated cells of the conjunctiva interacting with the corneal stroma.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500005
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2012007500023
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.45 n.5 2012
Fonte: | info:eu-repo/semantics/openAccess