Data/hora: 16/06/2024 01:01:26

Provedor de dados: | 56
País: | Brazil
Título: | Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy
Autores: | Kan,Minchen; Song,Lihong; Zhang,Xueqiang; Zhang,Jing; Fang,Pingping.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | High-mobility group box-1 (HMGB1); Toll-like receptor 4 (TLR4); Epilepsy; Severity; Drug resistance.
Resumo: | This study aimed to investigate the association of serum high-mobility group box-1 (HMGB1) and toll-like receptor 4 (TLR4) expressions with the risk of epilepsy as well as their correlations with disease severity and resistance to anti-epilepsy drugs. One hundred and five epilepsy patients and 100 healthy controls (HCs) were enrolled in this case-control study, and serum samples were collected from all participants to assess the HMGB1 and TLR4 expressions by enzyme-linked immunosorbent assay (ELISA). Both serum HMGB1 (P&lt;0.001) and TLR4 (P&lt;0.001) expressions were higher in epilepsy patients than in HCs, and they displayed good predictive values for risk of epilepsy. Moreover, HMGB1 was positively correlated with TLR4 level (r=0.735, P&lt;0.001). HMGB1 and TLR4 levels were both elevated in patients with an average seizure duration &gt;5 min compared to patients with a seizure duration ≤5 min (P=0.001 and P=0.014, respectively). Also, HMGB1 and TLR4 were increased in patients with seizure frequency &gt;3 times per month compared to patients with seizure frequency ≤3 times per month (both P=0.001). In addition, HMGB1 and TLR4 expressions were higher in intractable cases compared to drug-responsive cases (P&lt;0.001). In conclusion, both HMGB1 and TLR4 expressions were correlated with increased risk and severity of epilepsy and their level was higher in patients resistant to anti-epilepsy drugs.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000700603
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20197374
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.52 n.7 2019
Fonte: | info:eu-repo/semantics/openAccess