Data/hora: 04/06/2024 14:40:33

Provedor de dados: | 56
País: | Brazil
Título: | Human_Leishmaniasis@cytokines.bahia.br
Autores: | Barral-Netto,M.; Brodskyn,C.; Carvalho,E.M.; Barral,A.
Data: | 1998-01-01
Ano: | 1998
Palavras-chave: | Cytokines; Human leishmaniasis; Immunoregulation; IL-12; IL-10.
Resumo: | The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt;, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; opposing cytokine, and IL-12 as an IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; inducer. The effects of these cytokines were evaluated in terms of several parameters of the human immune response. IL-10 reduced lymphocyte proliferation, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; production and cytotoxic activity of responsive human peripheral blood mononuclear cells. Neutralization of IL-10 led to partial restoration of lymphoproliferation, IFN-&lt;FONT FACE="Symbol"&gt;g&lt;/font&gt; production and cytotoxic activity in unresponsive visceral leishmaniasis patients. IL-12 also restored the responses of peripheral blood mononuclear cells from visceral leishmaniasis patients. The responses obtained with IL-12 are higher than those obtained with anti-IL-10, even when anti-IL-10 is combined with anti-IL-4
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100021
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000100021
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.1 1998
Fonte: | info:eu-repo/semantics/openAccess