Data/hora: 16/06/2024 07:41:51

Provedor de dados: | 56
País: | Brazil
Título: | Antinociceptive effects of Cremophor EL orally administered to mice
Autores: | Tabarelli,Z.; Berlese,D.B.; Sauzem,P.D.; Mello,C.F.; Rubin,M.A.
Data: | 2003-01-01
Ano: | 2003
Palavras-chave: | Antinociception; Cremophor EL; Tail immersion test; Writhing test; Dipyrone; Morphine.
Resumo: | Surfactants are frequently used to improve solubilization of lipophilic drugs. Cremophor EL (CrEL) is a polyoxyethylated castor oil surfactant used to solubilize water-insoluble drugs such as anesthetic, antineoplastic, immunosuppressive and analgesic drugs, vitamins and new synthetic compounds, including potential analgesics. The antinociceptive effect of CrEL (3.2, 6.4 and 10.6 g/kg, in 10 ml/kg body weight, by gavage) on the abdominal writhing response induced by intraperitoneal administration of acetic acid (0.8%, 10 ml/kg body weight) and on the tail immersion test was investigated in mice. Control animals received castor oil (10 ml/kg body weight) or saline (0.9% NaCl, 10 ml/kg body weight). CrEL reduced nociception in a dose-dependent manner in both tests. At 10.6 g/kg, CrEL caused antinociception similar to that induced by dipyrone (300 mg/kg, by gavage) in the abdominal writhing test, and antinociception similar to that induced by morphine (20 mg/kg, by gavage) in the tail immersion test. The effect of castor oil was similar to that of saline in both assays. These data indicate that the appropriate controls should be used when evaluating the effects of potential antinociceptive agents dissolved in CrEL.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100016
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2003000100016
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.36 n.1 2003
Fonte: | info:eu-repo/semantics/openAccess