Data/hora: 09/06/2024 05:58:04

Provedor de dados: | 56
País: | Brazil
Título: | Cytomegalovirus infection in renal transplant recipients diagnosed by nested-PCR
Autores: | Aquino,V.H.; Figueiredo,L.T.M.
Data: | 2001-01-01
Ano: | 2001
Palavras-chave: | Cytomegalovirus; Polymerase chain reaction; Kidney transplantation.
Resumo: | A prospective study of cytomegalovirus (CMV) infection was carried out on 34 renal transplant recipients managed at a General Hospital in Ribeirão Preto, SP, Brazil. Serologic tests showed that all patients were infected with CMV before renal transplantation. Two nested-PCR techniques with primers that recognize sequences of the glycoprotein B (gB) and H (gH) genes were used for CMV detection in blood and urine samples during the post-transplantation period. CMV was detected more frequently in blood samples than in urine samples (P&lt;0.001). Thirty-three patients had CMV detected at least once in blood and/or urine samples. Seven of these patients (21.2%) were diagnosed as having symptomatic CMV infection and showed a worse clinical outcome, with a higher death rate (P = 0.03). No association between CMV viremia and graft rejection was observed. Nested-PCR was not useful to identify patients at risk for symptomatic CMV infection since only 21.2% of the patients with CMV infection were symptomatic.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000100011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2001000100011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.34 n.1 2001
Fonte: | info:eu-repo/semantics/openAccess