Data/hora: 04/06/2024 04:32:22

Provedor de dados: | 56
País: | Brazil
Título: | The role of osteoblasts in regulating hematopoietic stem cell activity and tumor metastasis
Autores: | Neiva,K.; Sun,Y.-X.; Taichman,R.S.
Data: | 2005-10-01
Ano: | 2005
Palavras-chave: | Osteoblasts; Hematopoietic stem cells; Bone marrow; Stromal-derived factor-1; CXCR4; Prostate cancer.
Resumo: | Bone marrow stromal cells are critical regulators of hematopoiesis. Osteoblasts are part of the stromal cell support system in bone marrow and may be derived from a common precursor. Several studies suggested that osteoblasts regulate hematopoiesis, yet the entire mechanism is not understood. It is clear, however, that both hematopoietic precursors and osteoblasts interact for the production of osteoclasts and the activation of resorption. We observed that hematopoietic stem cells (HSCs) regulate osteoblastic secretion of various growth factors, and that osteoblasts express some soluble factors exclusively in the presence of HSCs. Osteoblasts and hematopoietic cells are closely associated with each other in the bone marrow, suggesting a reciprocal relationship between them to develop the HSC niche. One critical component regulating the niche is stromal-derived factor-1 (SDF-1) and its receptor CXCR4 which regulates stem cell homing and, as we have recently demonstrated, plays a crucial role in facilitating those tumors which metastasize to bone. Osteoblasts produce abundant amounts of SDF-1 and therefore osteoblasts play an important role in metastasis. These findings are discussed in the context of the role of osteoblasts in marrow function in health and disease.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2005001000001
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.38 n.10 2005
Fonte: | info:eu-repo/semantics/openAccess