Data/hora: 10/06/2024 15:59:37

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Interruption of recently induced immune responses by oral administration of antigen
Autores: | Conde,A.A.; Stransky,B.; Faria,A.M.C.; Vaz,N.M.
Data: | 1998-03-01
Ano: | 1998
Palavras-chave: | Suppression; Antibody response; Oral tolerance; Ovalbumin.
Resumo: | Interest in oral tolerance has been renewed in the last few years as a possibility of intervention in human autoimmune diseases. An obstacle in this direction is that, although easily induced in animals virgin of contact with the antigen, oral tolerance becomes hard to induce in previously immunized animals. The present results show that there is an early period after primary immunization in which prolonged oral exposure to the antigen may arrest ongoing immune responses. Beyond this period, oral exposures to the antigen become ineffective and may actually boost immune responses. The end of the susceptible period coincides with the emergence of free specific antibodies in serum. However, the previous administration of purified anti-ovalbumin antibodies (40 µg) was unable to block the induction of oral tolerance to ovalbumin in normal mice
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000300008
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.3 1998
Fonte: | info:eu-repo/semantics/openAccess