Data/hora: 04/06/2024 04:38:01

Provedor de dados: | 56
País: | Brazil
Título: | Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients
Autores: | Donadi,E.A.; Voltarelli,J.C.; Paula-Santos,C.M.; Kimachi,T.; Ferraz,A.S.
Data: | 1998-04-01
Ano: | 1998
Palavras-chave: | HLA antigens; Alport's syndrome; MHC; Immunogenetics.
Resumo: | A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty of Medicine of Ribeirão Preto, São Paulo, Brazil. HLA-A, -B, -DR and -DQ antigens were typed using a complement-dependent microlymphocytotoxicity assay. A control white population (N = 403) from the same geographical area was also typed for HLA antigens. Although the frequencies of HLA-A and -B antigens of patients were not statistically different from controls, the frequency of HLA-DR2 antigen observed in patients (65%) was significantly increased in relation to controls (26%; P&amp;lt;0.001). The relative risk and etiologic fraction for HLA-DR2 antigen were 5.2 and 0.525, respectively. Although few immunological abnormalities have been shown in Alport's syndrome, in this report we emphasize the association of HLA molecules and Alport's syndrome. Besides the well-known inherited molecular defects encoded by type IV collagen genes in Alport's syndrome, the major histocompatibility alleles may be in linkage disequilibrium with these defective collagen genes
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400010
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000400010
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.4 1998
Fonte: | info:eu-repo/semantics/openAccess