Data/hora: 28/05/2024 17:51:15

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Effect of obesity on rat reproduction and on the development of their adult offspring
Autores: | Campos,K.E.; Volpato,G.T.; Calderon,I.M.P.; Rudge,M.V.C.; Damasceno,D.C.
Data: | 2008-02-01
Ano: | 2008
Palavras-chave: | Obesity; Offspring; Fertility; Wistar rats; Monosodium glutamate; Transgeneration.
Resumo: | The aim of the present study was to assess the reproductive parameters of obese Wistar rats and to determine the frequency of their obese adult offspring. Neonatal rats were divided into two groups: F1 generation, induced to obesity by monosodium glutamate (MSG; F1MSG, N = 30), and rats given saline (F1CON, N = 13). At 90 days of age all animals were mated, producing the F2 offspring (F2CON, N = 28; F2MSG, N = 15). Reproductive parameters (fertility, pregnancy, and delivery indexes) were evaluated in F1 rats. F2 newborns were weighed, and the obesity parameter for F1 and F2 generations was determined from months 5 to 7 of life. At month 7, periovarian fat was weighed and no differences were found. Mean newborn weight also did not differ. The F1 and F2MSG groups presented approximately 90% of obese rats since month 5 of life, whereas F1 and F2CON groups presented only 33%. There was no difference in periovarian weight among groups. Although obesity did not affect reproductive parameters, obese dams (F1MSG) were responsible for the appearance of obesity in the subsequent generation. Thus, obesity induced by neonatal MSG administration did not interfere with reproduction, but did provide a viable model for obesity in second-generation adult Wistar rats. This model might contribute to a better understanding of the pathophysiological mechanisms involved in transgenerational obesity.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2008005000001
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.41 n.2 2008
Fonte: | info:eu-repo/semantics/openAccess