Data/hora: 11/06/2024 15:15:52

Provedor de dados: | 56
País: | Brazil
Título: | Differential effects of lead and zinc on inhibitory avoidance learning in mice
Autores: | de Oliveira,F.S.; Viana,M.R.; Antoniolli,A.R.; Marchioro,M.
Data: | 2001-01-01
Ano: | 2001
Palavras-chave: | Lead; Zinc; Inhibitory avoidance; Memory.
Resumo: | We studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P&gt;0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P&lt;0.05; day 7: q = 4.42, P&lt;0.05; day 14: q = 5.65, P&lt;0.05; day 21: q = 3.96, P&lt;0.05, and day 28: q = 6.09, P&lt;0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P&lt;0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000100014
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2001000100014
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.34 n.1 2001
Fonte: | info:eu-repo/semantics/openAccess