Data/hora: 10/06/2024 04:45:52

Provedor de dados: | 56
País: | Brazil
Título: | Nitro-fatty acids: novel anti-inflammatory lipid mediators
Autores: | Rubbo,H.
Data: | 2013-09-01
Ano: | 2013
Palavras-chave: | Nitro-fatty acids; Antioxidants; Nitric oxide; Inflammation.
Resumo: | Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways. Here we discuss the mechanisms of nitro-fatty acid formation as well as their key chemical and biochemical properties. The electrophilic properties of nitro-fatty acids to activate anti-inflammatory signaling pathways are discussed in detail. A critical issue is the influence of nitroarachidonic acid on prostaglandin endoperoxide H synthases, redirecting arachidonic acid metabolism and signaling. We also analyze in vivo data supporting nitro-fatty acids as promising pharmacological tools to prevent inflammatory diseases.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000900728
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20133202
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.46 n.9 2013
Fonte: | info:eu-repo/semantics/openAccess