Data/hora: 04/06/2024 02:43:35

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients
Autores: | Maksud,F.A.N.; Kakehasi,A.M.; Barbosa,A.J.A.
Data: | 2013-04-01
Ano: | 2013
Palavras-chave: | Argyrophil cells; Endocrine cells; Obesity; Gastric mucosa; Metabolic syndrome.
Resumo: | Obesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI &gt;40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20132609
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.46 n.4 2013
Fonte: | info:eu-repo/semantics/openAccess