Data/hora: 09/06/2024 06:49:20

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Focal adhesion kinase signaling in cardiac hypertrophy and failure
Autores: | Franchini,K.G.; Clemente,C.F.M.Z.; Marin,T.M.
Data: | 2009-01-01
Ano: | 2009
Palavras-chave: | Focal adhesion kinase; Mechanical signaling; Cardiovascular system; Signal transduction.
Resumo: | Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100008
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2009000100008
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.42 n.1 2009
Fonte: | info:eu-repo/semantics/openAccess