Data/hora: 08/06/2024 11:51:57

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Leukocytosis, muscle damage and increased lymphocyte proliferative response after an adventure sprint race
Autores: | Tossige-Gomes,R.; Ottone,V.O.; Oliveira,P.N.; Viana,D.J.S.; Araújo,T.L.; Gripp,F.J.; Rocha-Vieira,E.
Data: | 2014-06-01
Ano: | 2014
Palavras-chave: | Strenuous exercise; Lymphocyte; Proliferation; Aspartate amino transferase; Immunosuppression.
Resumo: | The effect of an adventure sprint race (ASR) on T-cell proliferation, leukocyte count and muscle damage was evaluated. Seven young male runners completed an ASR in the region of Serra do Espinhaço, Brazil. The race induced a strong leukocytosis (6.22±2.04×103 cells/mm3 beforevs 14.81±3.53×103 cells/mm3after the race), marked by a significant increase of neutrophils and monocytes (P&lt;0.05), but not total lymphocytes, CD3+CD4+ or CD3+CD8+ cells. However, the T-cell proliferative response to mitogenic stimulation was increased (P=0.025) after the race, which contradicted our hypothesis that ASR, as a high-demand competition, would inhibit T-cell proliferation. A positive correlation (P=0.03, r=0.79) was observed between the proliferative response of lymphocytes after the race and the time to complete the race, suggesting that the proliferative response was dependent on exercise intensity. Muscle damage was evident after the race by increased serum levels of aspartate amino transferase (24.99±8.30 vs 50.61±15.76 U/L, P=0.003). The results suggest that humoral factors and substances released by damaged muscle may be responsible for lymphocyte activation, which may be involved in muscle recovery and repair.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600492
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20143187
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.47 n.6 2014
Fonte: | info:eu-repo/semantics/openAccess