Data/hora: 13/06/2024 16:06:11

Provedor de dados: | 56
País: | Brazil
Título: | Association of the 894G&gt;T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina
Autores: | Iturry-Yamamoto,G.R.; Moriguchi,E.H.; Zago,A.C.; Alho,C.S.; Zago,A.J.
Data: | 2007-04-01
Ano: | 2007
Palavras-chave: | Nitric oxide synthase; Gene; Polymorphism; Unstable angina; Coronary.
Resumo: | The 894G&gt;T polymorphism of the endothelial constitutive nitric oxide synthase gene consists of the substitution of a guanine base by a thymine at the 894th nucleotide of the gene. An association of this polymorphism with acute coronary syndromes has been described, only when in combination with other polymorphisms of this gene. The aim of the present study was to search for an association between this polymorphism and unstable angina in a southern Brazilian population. In a case-control study, 156 patients (group 1 (N = 83): unstable angina, group 2 (N = 73): stable angina) were genotyped by PCR and digestion of the product. Univariate analysis demonstrated that the minimal luminal diameter and the degree of stenosis of the culprit lesion differed between groups (P = 0.006 and 0.005, respectively). In addition, the frequencies of the T allele and of the T allele carriers (combined TT and TG genotypes) were significantly higher in the group with unstable angina (41.6 vs 28.8%; P = 0.025, Pearson chi-square test, and 73.5 vs 45.2%; P = 0.001, Pearson chi-square test, respectively). Multivariate logistic regression showed that the frequency of the T allele carriers was the only variable with a predictive value for unstable angina, when controlled for the other variables (6.1 (95% CI = 2.55-14.43); P &lt; 0.001). Thus, in a homogenous group of patients, the endothelial constitutive nitric oxide synthase 894G&gt;T polymorphism was associated with unstable angina. We suggest that this polymorphism may be a genetic risk factor for unstable angina.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400005
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006005000072
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.40 n.4 2007
Fonte: | info:eu-repo/semantics/openAccess