Data/hora: 11/06/2024 11:12:06

Provedor de dados: | 56
País: | Brazil
Título: | Response to an oral calcium load in nephrolithiasis patients with fluctuating parathyroid hormone and ionized calcium levels
Autores: | Gomes,S.A.; Lage,A.; Lazaretti-Castro,M.; Vieira,J.G.H.; Heilberg,I.P.
Data: | 2004-09-01
Ano: | 2004
Palavras-chave: | Parathyroid hormone; Calcium; Hyperparathyroidism; Hypercalciuria; Nephrolithiasis; Bone mineral density.
Resumo: | the response to an oral calcium load test was assessed in 17 hypercalciuric nephrolithiasis patients who presented elevated parathyroid hormone (PTH) irrespective of the ionized calcium (sCa2+) levels. Blood samples were collected at baseline (0 min) and at 60 and 180 min after 1 g calcium load for serum PTH, total calcium, sCa2+, and 1.25(OH)2D3 determinations. According to the sCa2+ level at baseline, patients were classified as normocalcemic (N = 9) or hypercalcemic (N = 8). Six healthy subjects were also evaluated as controls. Bone mineral density was reduced in 14/17 patients. In the normocalcemic group, mean PTH levels at 0, 60 and 180 min (95 ± 76, 56 ± 40, 57 ± 45 pg/ml, respectively) did not differ from the hypercalcemic group (130 ± 75, 68 ± 35, 80 ± 33 pg/ml) but were significantly higher compared to healthy subjects despite a similar elevation in sCa2+ after 60 and 180 min vs baseline in all 3 groups. Mean total calcium and 1.25(OH)2D3 were similar in the 3 groups. Additionally, we observed that 5 of 9 normocalcemic patients presented a significantly higher concentration-time curve for serum PTH (AUC0',60',180') than the other 4 patients and the healthy subjects, suggesting a primary parathyroid dysfunction. These data suggest that the individual response to an oral calcium load test may be a valuable dynamic tool to disclose a subtle primary hyperparathyroidism in patients with high PTH and fluctuating sCa2+ levels, avoiding repeated measurements of both parameters.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2004000900013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.37 n.9 2004
Fonte: | info:eu-repo/semantics/openAccess