Data/hora: 03/06/2024 18:40:18

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Veratridine increases the survival of retinal ganglion cells in vitro
Autores: | Pereira,S.P.F.; Araujo,E.G.
Data: | 1997-12-01
Ano: | 1997
Palavras-chave: | Veratridine; Retinal ganglion cells; Natural cell death; Development; Retina.
Resumo: | Neuronal cell death is an important phenomenon involving many biochemical pathways. This degenerative event has been studied to understand how the cells activate the mechanisms that lead to self-destruction. Target cells and afferent cells play a relevant role in the regulation of natural cell death. We studied the effect of veratridine (1.5, 3.0, 4.5 and 6.0 µM) on the survival of neonatal rat retinal ganglion cells in vitro. Veratridine (3.0 µM), a well-known depolarizing agent that opens the Na+ channel, promoted a two-fold increase in the survival of retinal ganglion cells kept in culture for 48 h. This effect was dose-dependent and was blocked by 1.0 µM tetrodotoxin (a classical voltage-dependent Na+ channel blocker) and 30.0 µM flunarizine (a Na+ and Ca2+ channel blocker). These results indicate that electrical activity is also important for the maintenance of retinal ganglion cell survival in vitro
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200014
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997001200014
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.12 1997
Fonte: | info:eu-repo/semantics/openAccess