Data/hora: 10/06/2024 05:31:20

Provedor de dados: | 56
País: | Brazil
Título: | Eosinophil-active chemokines: assessment of in vivo activity
Autores: | Teixeira,M.M.
Data: | 1998-01-01
Ano: | 1998
Palavras-chave: | Eosinophils chemokines eotaxin MIP-1&lt; FONT FACE=Symbol&gt; A&lt; /font&gt; Chemokine receptors.
Resumo: | The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100003
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1998000100003
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.31 n.1 1998
Fonte: | info:eu-repo/semantics/openAccess