Data/hora: 02/06/2024 04:40:48

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Eosinophil-active chemokines: assessment of in vivo activity	
Autores: 	Teixeira,M.M.	
Data: 	1998-01-01	
Ano: 	1998	
Palavras-chave: 	Eosinophils chemokines eotaxin MIP-1&lt; FONT FACE=Symbol&gt; A&lt; /font&gt; Chemokine receptors.	
Resumo: 	The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt; induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1&lt;FONT FACE="Symbol"&gt;a&lt;/font&gt;. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100003	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1998000100003	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.31 n.1 1998	
Fonte: 	info:eu-repo/semantics/openAccess