Data/hora: 10/06/2024 12:44:27

Provedor de dados: | 56
País: | Brazil
Título: | lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer
Autores: | Song,Linlin; Wang,Linlin; Pan,Xiaoli; Yang,Caihong.
Data: | 2020-01-01
Ano: | 2020
Palavras-chave: | LncRNA; OIP5-AS1; Cervical cancer; MiR-143-3p; ROCK1.
Resumo: | Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. Here, we demonstrated that lncRNA OIP5-AS1 was upregulated in cervical cancer and was correlated with poor prognosis by bioinformatics studies. OIP5-AS1 depletion inhibited cell proliferation and promoted cell apoptosis in cervical cancer cells. Furthermore, we clarified that ROCK1 was the downstream effector of OIP5-AS1 and OIP5-AS1 acted as a molecular sponge of miR-143-3p. Finally, we verified that OIP5-AS1 exerted its function in the regulation of cervical cancer progression via interacting with miR-143-3p to regulate ROCK1 expression. Our study revealed novel mechanisms about how lncRNA OIP5-AS1 executed its function in cervical cancer and thus provided potential therapeutic targets for the disease.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000100608
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20198883
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.53 n.1 2020
Fonte: | info:eu-repo/semantics/openAccess