Data/hora: 05/06/2024 01:09:21

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Interference of propylene glycol with the hole-board test	
Autores: 	Lourenço da Silva,A.; Elisabetsky,E.	
Data: 	2001-04-01	
Ano: 	2001	
Palavras-chave: 	Screening; Anxiolytic drugs; Propylene glycol; Diazepam; Solvents; Hole-board.	
Resumo: 	Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the head-dipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P&lt;0.05, ANOVA/Student-Newman-Keuls), an effect comparable to that obtained with 0.5 mg/kg diazepam (from 33.83 ± 4.39 to 54 ± 3.8, P&lt;0.01, ANOVA/Student-Newman-Keuls). These results demonstrate that 30% propylene glycol has significant anxiolytic effects in this model and therefore cannot be used as an innocuous solvent.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400016	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2001000400016	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.34 n.4 2001	
Fonte: 	info:eu-repo/semantics/openAccess