Data/hora: 10/06/2024 09:03:41

Provedor de dados: | 56
País: | Brazil
Título: | Responsiveness of glycogen breakdown to cyclic AMP in perfused liver from rats with insulin-induced hypoglycemia
Autores: | Vardanega-Peicher,M.; Curi,R.; Pagliarini e Silva,S.; Nascimento,K.F.; Bazotte,R.B.
Data: | 2003-01-01
Ano: | 2003
Palavras-chave: | Insulin-induced hypoglycemia; Cyclic AMP; Glycogen breakdown; Liver metabolism.
Resumo: | The responsiveness of glycogen breakdown to cAMP was investigated in isolated perfused liver from male Wistar fed rats (200-220 g) with insulin-induced hypoglycemia. The activation of glycogenolysis by 3 µM cAMP was decreased (P&lt;0.05) in livers from rats with hypoglycemia induced by the administration of insulin or during the direct infusion of insulin into the isolated liver. The direct effect of insulin on glycogen catabolism promoted by 3 µM cAMP occurred as early as 3 min after starting insulin infusion. In contrast, the cAMP agonists resistant to phosphodiesterases, 8Br-cAMP and 6MB-cAMP, used at the same concentration as cAMP, i.e., 3 µM, did not modify the effect of insulin. The data suggest that the decreased hepatic responsiveness of glycogen breakdown during insulin-induced hypoglycemia is a direct effect of insulin decreasing the intracellular levels of cAMP.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100007
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2003000100007
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.36 n.1 2003
Fonte: | info:eu-repo/semantics/openAccess