Data/hora: 09/06/2024 12:39:45

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats	
Autores: 	Molchanov,M.L.; Guimarães,F.S.	
Data: 	1999-12-01	
Ano: 	1999	
Palavras-chave: 	Periaqueductal gray; Metabotropic glutamate receptors; Defense behavior; T-ACPD; Open-field; Rats.	
Resumo: 	The behavioral effects of trans-(±)-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD), a metabotropic glutamate receptor (mGluR) agonist, or 0.9% (w/v) saline, injected into the dorsal periaqueductal gray (DPAG), was investigated. Male Wistar rats showed defense reactions characterized by jumps toward the top edges of the cages (saline = 0 vs t-ACPD = 6.0, medians P&amp;lt;0.05) and gallops (saline = 0 vs t-ACPD = 10.0, medians P&amp;lt;0.05) during the 60-s period after the beginning of the injection. In another experiment animals were placed inside an open arena for 5 min immediately after injection. Their behavior was recorded by a video camera and a computer program analyzed the videotapes. Eleven of fifteen rats injected with t-ACPD showed a short-lasting (about 1 min) flight reaction. No saline-treated animal showed this reaction (P&amp;lt;0.0005, chi-square test). The drug induced an increase in turning behavior (P = 0.002, MANOVA) and a decrease in the number of rearings (P&amp;lt;0.001, MANOVA) and grooming episodes (P&amp;lt;0.001, MANOVA). These results suggest that mGluRs play a role in the control of defense reactions in the DPAG.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200013	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X1999001200013	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.32 n.12 1999	
Fonte: 	info:eu-repo/semantics/openAccess