Data/hora: 04/06/2024 13:25:41

Provedor de dados: | 56
País: | Brazil
Título: | Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry
Autores: | Yeh,E.; Kimura,L.; Errera,F.I.V.; Angeli,C.B.; Mingroni-Netto,R.C.; Silva,M.E.R.; Canani,L.H.S.; Passos-Bueno,M.R.
Data: | 2008-06-01
Ano: | 2008
Palavras-chave: | Association study; Adiponectin receptors; Type 2 diabetes; Polymorphism for ancestry-admixture mapping; HDL cholesterol; Association of ADIPOR1 with DM2.
Resumo: | Association studies between ADIPOR1 genetic variants and predisposition to type 2 diabetes (DM2) have provided contradictory results. We determined if two single nucleotide polymorphisms (SNP c.-8503G&gt;A and SNP c.10225C&gt;G) in regulatory regions of ADIPOR1 in 567 Brazilian individuals of European (EA; N = 443) or African (AfA; N = 124) ancestry from rural (quilombo remnants; N = 439) and urban (N = 567) areas. We detected a significant effect of ethnicity on the distribution of the allelic frequencies of both SNPs in these populations (EA: -8503A = 0.27; AfA: -8503A = 0.16; P = 0.001 and EA: 10225G = 0.35; AfA: 10225G = 0.51; P &lt; 0.001). Neither of the polymorphisms were associated with DM2 in the case-control study in EA (SNP c.-8503G&gt;A: DM2 group -8503A = 0.26; control group -8503A = 0.30; P = 0.14/SNP 10225C&gt;G: DM2 group 10225G = 0.37; control group 10225G = 0.32; P = 0.40) and AfA populations (SNP c.-8503G&gt;A: DM2 group -8503A = 0.16; control group -8503A = 0.15; P = 0.34/SNP 10225C&gt;G: DM2 group 10225G = 0.51; control group 10225G = 0.52; P = 0.50). Similarly, none of the polymorphisms were associated with metabolic/anthropometric risk factors for DM2 in any of the three populations, except for HDL cholesterol, which was significantly higher in AfA heterozygotes (GC = 53.75 ± 17.26 mg/dL) than in homozygotes. We conclude that ADIPOR1 polymorphisms are unlikely to be major risk factors for DM2 or for metabolic/anthropometric measurements that represent risk factors for DM2 in populations of European and African ancestries.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600005
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2008000600005
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.41 n.6 2008
Fonte: | info:eu-repo/semantics/openAccess