Data/hora: 04/06/2024 19:08:40

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice	
Autores: 	Bocco,B.M.; Fernandes,G.W.; Lorena,F.B.; Cysneiros,R.M.; Christoffolete,M.A.; Grecco,S.S.; Lancellotti,C.L.; Romoff,P.; Lago,J.H.G.; Bianco,A.C.; Ribeiro,M.O.	
Data: 	2016-03-01	
Ano: 	2016	
Palavras-chave: 	Obesity; Caffeic acid; Ferulic acid; Metabolic syndrome.	
Resumo: 	Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300604	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431X20155003	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.49 n.3 2016	
Fonte: 	info:eu-repo/semantics/openAccess