Data/hora: 16/06/2024 06:23:08

Provedor de dados: | 56
País: | Brazil
Título: | Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis
Autores: | Baptista,M.S.; Wainwright,M.
Data: | 2011-01-01
Ano: | 2011
Palavras-chave: | Tropical diseases; Photodynamic therapy; Singlet oxygen; Photosensitisers; Leishmania; Chagas’ disease.
Resumo: | A photodynamic effect occurs when photosensitiser molecules absorb light and dissipate the absorbed energy by transferring it to biological acceptors (usually oxygen), generating an excess of reactive species that are able to force cells into death pathways. Several tropical diseases present physiopathological aspects that are accessible to the application of a photosensitiser and local illumination. In addition, disease may be transmitted through infected blood donations, and many of the aetiological agents associated with tropical diseases have been shown to be susceptible to the photodynamic approach. However, there has been no systematic investigation of the application of photoantimicrobial agents in the various presentations, whether to human disease or to the disinfection of blood products or even as photo-insecticides. We aim in this review to report the advances in the photoantimicrobial approach that are beneficial to the field of anti-parasite therapy and also have the potential to facilitate the development of low-cost/high-efficiency protocols for underserved populations.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000100001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2010007500141
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.44 n.1 2011
Fonte: | info:eu-repo/semantics/openAccess