Data/hora: 10/06/2024 11:16:13

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis
Autores: | Slavov,S.N.; Gimenes Teixeira,H.L.; Rego,E.M.
Data: | 2010-07-01
Ano: | 2010
Palavras-chave: | MicroRNAs; Gene expression; Leukemia; Acute lymphoblastic leukemia; T cells.
Resumo: | Micro-ribonucleic acids (microRNAs) are small molecules containing 20-23 nucleotides. Despite their small size, it is likely that almost every cellular process is regulated by them. Moreover, aberrant microRNA expression has been involved in the development of various diseases, including cancer. Although many data are available about the role of microRNAs in various lymphoproliferative disorders, their impact on the development of acute lymphoblastic leukemia of T-cell progenitors is largely unknown. In this review, we present recent information about how specific microRNAs are expressed and regulated during malignant T-lymphopoiesis and about their role during normal hematopoiesis.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700003
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2010007500057
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.43 n.7 2010
Fonte: | info:eu-repo/semantics/openAccess