Data/hora: 09/06/2024 12:41:34

Provedor de dados: | 56
País: | Brazil
Título: | Understanding the mechanisms of lung mechanical stress
Autores: | Garcia,C.S.N.B.; Prota,L.F.M.; Morales,M.M.; Romero,P.V.; Zin,W.A.; Rocco,P.R.M.
Data: | 2006-06-01
Ano: | 2006
Palavras-chave: | Mechanical forces; Mechanosensors; Mechanotransduction; Cell-cell interactions; Cytokines; Extracellular matrix.
Resumo: | Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These forces include changes in stress (force per unit area) or strain (any forced change in length in relation to the initial length) and shear stress (the stress component parallel to a given surface). The responses of cells to mechanical forces are the result of the cell's ability to sense and transduce these stimuli into intracellular signaling pathways able to communicate the information to its interior. This review will focus on the modulation of intracellular pathways by lung mechanical forces and the intercellular signaling. A better understanding of the mechanisms by which lung cells transduce physical forces into biochemical and biological signals is of key importance for identifying targets for the treatment and prevention of physical force-related disorders.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600001
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006000600001
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.39 n.6 2006
Fonte: | info:eu-repo/semantics/openAccess