Data/hora: 05/06/2024 00:27:18

Provedor de dados: | 56
País: | Brazil
Título: | Effects of entorhinal cortex lesions on memory in different tasks
Data: | 1997-06-01
Ano: | 1997
Palavras-chave: | Entorhinal cortex; Memory; NMDA lesions.
Resumo: | Lesions of the entorhinal cortex produce retrograde memory impairment in both animals and humans. Here we report the effects of bilateral entorhinal cortex lesions caused by the stereotaxic infusion of N-methyl-D-aspartate (NMDA) in rats at two different moments, before or after the training session, on memory of different tasks: two-way shuttle avoidance, inhibitory avoidance and habituation to an open field. Pre- or post-training entorhinal cortex lesions caused an impairment of performance in the shuttle avoidance task, which agrees with the previously described role of this area in the processing of memories acquired in successive sessions. In the inhibitory avoidance task, only the post-training lesions had an effect (amnesia). No effect was observed on the open field task. The findings suggest that the role of the entorhinal cortex in memory processing is task-dependent, perhaps related to the complexity of each task
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000600011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000600011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.6 1997
Fonte: | info:eu-repo/semantics/openAccess