Data/hora: 02/06/2024 05:13:34

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux
Autores: | Liu,C.; Wang,H.; Liu,K.
Data: | 2016-01-01
Ano: | 2016
Palavras-chave: | Gastroesophageal reflux disease; Adult; Proton pump inhibitors; Meta-analysis.
Resumo: | The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000700704
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20165149
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.49 n.7 2016
Fonte: | info:eu-repo/semantics/openAccess