Data/hora: 09/06/2024 12:33:19

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Autores: | Borges,F.T.; Reis,L.A.; Schor,N.
Data: | 2013-10-01
Ano: | 2013
Palavras-chave: | Extracellular vesicles; Cell biology; Kidney diseases; Diagnosis; Treatment.
Resumo: | Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of well-characterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000824
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20132964
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.46 n.10 2013
Fonte: | info:eu-repo/semantics/openAccess