Data/hora: 17/06/2024 07:23:26

Provedor de dados: | 56
País: | Brazil
Título: | Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms
Data: | 1997-03-01
Ano: | 1997
Palavras-chave: | Bothrops atrox; Snake venom; Antivenom; Neutralization; Antioquia; Chocó.
Resumo: | Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atrox from Antioquia and Chocó (Colombia). The following antivenoms were used: a) polyvalent (crotaline) antivenom produced by Instituto Clodomiro Picado (Costa Rica), b) monovalent antibothropic antivenom produced by Instituto Nacional de Salud-INS (Bogotá), and c) a new monovalent anti-B. atrox antivenom produced with the venom of B. atrox from Antioquia and Chocó. The three antivenoms neutralized all toxic activities tested albeit with different potencies. The new monovalent anti-B. atrox antivenom showed the highest neutralizing ability against edema-forming and defibrinating effects of B. atrox venom (41 ± 2 and 100 ± 32 µl antivenom/mg venom, respectively), suggesting that it should be useful in the treatment of B. atrox envenomation in Antioquia and Chocó
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000300011
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.3 1997
Fonte: | info:eu-repo/semantics/openAccess