Data/hora: 07/06/2024 15:07:02

Provedor de dados: | 56
País: | Brazil
Título: | High-frequency electroacupuncture versus carprofen in an incisional pain model in rats
Autores: | Teixeira,F.M.; Castro,L.L.; Ferreira,R.T.; Pires,P.A.; Vanderlinde,F.A.; Medeiros,M.A.
Data: | 2012-12-01
Ano: | 2012
Palavras-chave: | Hyperalgesia; Plantar incision; Acupuncture; Zusanli point; Non-steroidal anti-inflammatory.
Resumo: | The objective of the present study was to compare the effect of electroacupuncture (EA) and carprofen (CP) on postoperative incisional pain using the plantar incision (PI) model in rats. A 1-cm longitudinal incision was made through skin, fascia and muscles of a hind paw of male Wistar rats and the development of mechanical and thermal hypersensitivity was determined over 4 days using the von Frey and Hargreaves methods, respectively. Based on the experimental treatments received on the third postoperative day, the animals were divided into the following groups: PI+CP (CP, 2 mg/kg, po); PI+EAST36 (100-Hz EA applied bilaterally at the Zusanli point (ST36)); PI+EANP (EA applied to a non-acupoint region); PI+IMMO (immobilization only); PI (vehicle). In the von Frey test, the PI+EAST36 group had higher withdrawal force thresholds in response to mechanical stimuli than the PI, PI+IMMO and PI+EANP groups at several times studied. Furthermore, the PI+EAST36 group showed paw withdrawal thresholds in response to mechanical stimuli that were similar to those of the PI+CP group. In the Hargreaves test, all groups had latencies higher than those observed with PI. The PI+EAST36 group was similar to the PI+IMMO, PI+EANP and PI+CP groups. We conclude that 100-Hz EA at the ST36 point, but not at non-acupoints, can reduce mechanical nociception in the rat model of incisional pain, and its effectiveness is comparable to that of carprofen.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200014
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2012007500133
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.45 n.12 2012
Fonte: | info:eu-repo/semantics/openAccess