Data/hora: 29/05/2024 06:00:34

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation
Data: | 1997-02-01
Ano: | 1997
Palavras-chave: | Memory consolidation; Hippocampus and amygdala; Entorhinal cortex; Parietal cortex.
Resumo: | A total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were trained in a step-down inhibitory avoidance task. At various times after training (0, 30, 60 or 90 min) the animals received a 0.5-µl microinfusion of vehicle (saline) or 0.5 µg of muscimol dissolved in the vehicle. A retention test was carried out 24 h after training. Retention test performance was hindered by muscimol administered into both the hippocampus and amygdala at 0 but not at 30 min posttraining. The drug was amnestic when given into the entorhinal cortex 30, 60 or 90 min after training, or into the parietal cortex 60 or 90 min after training, but not before. These findings suggest a sequential entry operation, during the posttraining period, of the hippocampus and amygdala, the entorhinal cortex, and the posterior parietal cortex in memory processing
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000200012
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997000200012
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.2 1997
Fonte: | info:eu-repo/semantics/openAccess