Data/hora: 17/06/2024 01:37:23

Provedor de dados: | 56
País: | Brazil
Título: | Distribution of HCV genotypes among different exposure categories in Brazil
Autores: | Oliveira,M.L.A.; Bastos,F.I.; Sabino,R.R.; Paetzold,U.; Schreier,E.; Pauli,G.; Yoshida,C.F.T.
Data: | 1999-03-01
Ano: | 1999
Palavras-chave: | HCV; HCV genotypes; Brazil.
Resumo: | Hepatitis C virus (HCV) infection is widespread and responsible for more than 60% of chronic hepatitis cases. HCV presents a genetic variability which has led to viral classification into at least 6 genotypes and a series of subtypes. These variants present characteristic geographical distribution, but their association with different responses to treatment with interferon and severity of disease still remains controversial. The aim of this study was to investigate the patterns of distribution of HCV genotypes among different exposure categories in Brazil. Two hundred and fifty anti-HCV positive samples were submitted to HCV-RNA detection by RT-PCR and their genotype was determined by restriction fragment length polymorphism (RFLP) analysis. In addition, the genotype/subtype of 60 samples was also determined by a reverse hybridization assay. HCV 1 was the most prevalent (72.0%), followed by type 3 (25.3%), HCV 2 (2.0%) and HCV 4 (0.7%). The HCV genotype distribution varied among the different exposure categories, with HCV 1 being more frequent among blood donors, hemophiliacs and hemodialysis patients. A high frequency of HCV 3 was observed in cirrhotic patients, blood donors from the South of Brazil and injecting drug users (IDUs). The general distribution of the HCV genotype in Brazil is similar to that in other regions of the world.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300005
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999000300005
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.3 1999
Fonte: | info:eu-repo/semantics/openAccess