Data/hora: 04/06/2024 16:37:47

Provedor de dados: | 56
País: | Brazil
Título: | The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal
Autores: | Benetello,V.; Sakamoto,F.C.; Giglio,F.P.M.; Sakai,V.T.; Calvo,A.M.; Modena,K.C.S.; Colombini,B.L.; Dionísio,T.J.; Lauris,J.R.P.; Faria,F.A.C.; Santos,C.F.
Data: | 2007-08-01
Ano: | 2007
Palavras-chave: | Acute postoperative pain; Cyclooxygenase inhibitors; Lower third molar; Non-steroidal anti-inflammatory drugs; Piroxicam; Valdecoxib.
Resumo: | We compared the clinical efficacy of orally administered valdecoxib and piroxicam for the prevention of pain, trismus and swelling after removal of horizontally and totally intrabony impacted lower third molars. Twenty-five patients were scheduled to undergo removal of symmetrically positioned lower third molars in two separate appointments. Valdecoxib (40 mg) or piroxicam (20 mg) was administered in a double-blind, randomized and crossed manner for 4 days after the surgical procedures. Objective and subjective parameters were recorded for comparison of postoperative courses. Both agents were effective for postoperative pain relief (N = 19). There was a similar mouth opening at suture removal compared with the preoperative values (86.14 ± 4.36 and 93.12 ± 3.70% of the initial measure for valdecoxib and piroxicam, respectively; ANOVA). There was no significant difference regarding the total amount of rescue medication taken by the patients treated with valdecoxib or piroxicam (173.08 ± 91.21 and 461.54 ± 199.85 mg, respectively; Wilcoxon test). There were no significant differences concerning the swelling observed on the second postoperative day compared to baseline measures (6.15 ± 1.84 and 8.46 ± 2.04 mm for valdecoxib and piroxicam, respectively; ANOVA) or on the seventh postoperative day (1.69 ± 1.61 and 2.23 ± 2.09 mm for valdecoxib and piroxicam, respectively; ANOVA). The cyclooxygenase-2 selective inhibitor valdecoxib is as effective as the non-selective cyclooxygenase inhibitor piroxicam for pain, trismus and swelling control after removal of horizontally and totally intrabony impacted lower third molars.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800015
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006005000123
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.40 n.8 2007
Fonte: | info:eu-repo/semantics/openAccess