Data/hora: 08/06/2024 13:36:02

Provedor de dados: | 56
País: | Brazil
Título: | Vancomycin-resistant enterococcus outbreak in a pediatric intensive care unit: report of successful interventions for control and prevention
Autores: | Carmona,F.; Prado,S.I.; Silva,M.F.I.; Gaspar,G.G.; Bellissimo-Rodrigues,F.; Martinez,R.; Matsuno,A.K.; Carlotti,A.P.C.P.
Data: | 2012-02-01
Ano: | 2012
Palavras-chave: | Infections; Antibiotics misuse; Drug resistance; Vancomycin-resistant enterococcus.
Resumo: | The objective of this study is to retrospectively report the results of interventions for controlling a vancomycin-resistant enterococcus (VRE) outbreak in a tertiary-care pediatric intensive care unit (PICU) of a University Hospital. After identification of the outbreak, interventions were made at the following levels: patient care, microbiological surveillance, and medical and nursing staff training. Data were collected from computer-based databases and from the electronic prescription system. Vancomycin use progressively increased after March 2008, peaking in August 2009. Five cases of VRE infection were identified, with 3 deaths. After the interventions, we noted a significant reduction in vancomycin prescription and use (75% reduction), and the last case of VRE infection was identified 4 months later. The survivors remained colonized until hospital discharge. After interventions there was a transient increase in PICU length-of-stay and mortality. Since then, the use of vancomycin has remained relatively constant and strict, no other cases of VRE infection or colonization have been identified and length-of-stay and mortality returned to baseline. In conclusion, we showed that a bundle intervention aiming at a strict control of vancomycin use and full compliance with the Hospital Infection Control Practices Advisory Committee guidelines, along with contact precautions and hand-hygiene promotion, can be effective in reducing vancomycin use and the emergence and spread of vancomycin-resistant bacteria in a tertiary-care PICU.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000200011
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2012007500005
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.45 n.2 2012
Fonte: | info:eu-repo/semantics/openAccess