Data/hora: 09/06/2024 00:42:33

Provedor de dados: | 56
País: | Brazil
Título: | Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
Autores: | Colombo,N.B.R.; Rangel,M.P.; Martins,V.; Hage,M.; Gelain,D.P.; Barbeiro,D.F.; Grisolia,C.K.; Parra,E.R.; Capelozzi,V.L.
Data: | 2015-09-01
Ano: | 2015
Palavras-chave: | Pequi; Caryocar brasiliense Camb; Oxidative stress; Lung cancer; Urethane; Molecular biology.
Resumo: | The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900852
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20154467
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.48 n.9 2015
Fonte: | info:eu-repo/semantics/openAccess