Data/hora: 10/06/2024 18:21:07

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene
Autores: | Sasahara,R.M.; Takahashi,C.; Sogayar,M.C.; Noda,M.
Data: | 1999-07-01
Ano: | 1999
Palavras-chave: | RECK transformation suppressor gene; Reversion; Transcriptional regulation; Sp1 family; Tumor suppressor genes.
Resumo: | The RECK gene was initially isolated as a transformation suppressor gene encoding a novel membrane-anchored glycoprotein and later found to suppress tumor invasion and metastasis by regulating matrix metalloproteinase-9. Its expression is ubiquitous in normal tissues, but undetectable in many tumor cell lines and in fibroblastic lines transformed by various oncogenes. The RECK gene promoter has been cloned and characterized. One of the elements responsible for the oncogene-mediated downregulation of mouse RECK gene is the Sp1 site, where the Sp1 and Sp3 factors bind. Sp1 transcription factor family is involved in the basal level of promoter activity of many genes, as well as in dynamic regulation of gene expression; in a majority of cases as a positive regulator, or, as exemplified by the oncogene-mediated suppression of RECK gene expression, as a negative transcription regulator. The molecular mechanisms of the downregulation of mouse RECK gene and other tumor suppressor genes are just beginning to be uncovered. Understanding the regulation of these genes may help to develop strategies to restore their expression in tumor cells and, hence, suppress the cells' malignant behavior.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700014
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1999000700014
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.32 n.7 1999
Fonte: | info:eu-repo/semantics/openAccess