Data/hora: 08/06/2024 13:30:52

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Epidemiological and functional implications of molecular variants of human papillomavirus
Autores: | Sichero,L.; Villa,L.L.
Data: | 2006-06-01
Ano: | 2006
Palavras-chave: | Human papillomavirus; DNA sequencing; Oncogenic potential; Cervical cancer; Immunity; Epidemiology.
Resumo: | Human papillomavirus genomes are classified into molecular variants when they present more than 98% of similarity to the prototype sequence within the L1 gene. Comparative nucleotide sequence analyses of these viruses have elucidated some features of their phylogenetic relationship. In addition, human papillomavirus intratype variability has also been used as an important tool in epidemiological studies of viral transmission, persistence and progression to clinically relevant cervical lesions. Until the present, little has been published concerning the functional significance of molecular variants. It has been shown that nucleotide variability within the long control region leads to differences in the binding affinity of some cellular transcriptional factors and to the enhancement of the expression of E6 and E7 oncogenes. Furthermore, in vivo and in vitro studies revealed differences in E6 and E7 biochemical and biological properties among molecular variants. Nevertheless, further correlation with additional functional information is needed to evaluate the significance of genome intratypic variability. These results are also important for the development of vaccines and to determine the extent to which immunization with L1 virus-like particles of one variant could induce antibodies that cross-neutralize other variants.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600002
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2006000600002
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.39 n.6 2006
Fonte: | info:eu-repo/semantics/openAccess