Data/hora: 03/06/2024 18:18:33

Provedor de dados: | 56
País: | Brazil
Título: | Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats
Autores: | Brito,J.O.; Ponciano,K.; Figueroa,D.; Bernardes,N.; Sanches,Í.C.; Irigoyen,M.C.; De Angelis,K.
Data: | 2008-09-01
Ano: | 2008
Palavras-chave: | Female rats; Fructose; Blood pressure; Insulin resistance; Parasympathetic nervous system.
Resumo: | The objective of the present study was to identify metabolic, cardiovascular and autonomic changes induced by fructose overload administered in the drinking water of rats for 8 weeks. Female Wistar rats (200-220 g) were divided into 2 groups: control (N = 8) and fructose-fed rats (N = 5; 100 mg/L fructose in drinking water for 8 weeks). The autonomic control of heart rate was evaluated by pharmacological blockade using atropine (3 mg/kg) and propranolol (4 mg/kg). The animals were submitted to an intravenous insulin tolerance test (ITT) and to blood glucose measurement. The fructose overload induced a significant increase in body weight (~10%) and in fasting glycemia (~28%). The rate constant of glucose disappearance (KITT) during ITT was lower in fructose-fed rats (3.25 ± 0.7%/min) compared with controls (4.95 ± 0.3%/min, P &lt; 0.05) indicating insulin resistance. The fructose-fed group presented increased arterial pressure compared to controls (122 ± 3 vs 108 ± 1 mmHg, P &lt; 0.05) and a reduction in vagal tonus (31 ± 9 vs 55 ± 5 bpm in controls, P &lt; 0.05). No changes in sympathetic tonus were observed. A positive correlation, tested by the Pearson correlation, was demonstrable between cardiac vagal tonus and KITT (r = 0.8, P = 0.02). These data provided new information regarding the role of parasympathetic dysfunction associated with insulin resistance in the development of early metabolic and cardiovascular alterations induced by a high fructose diet.
Tipo: | Info:eu-repo/semantics/other
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900010
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2008005000030
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.41 n.9 2008
Fonte: | info:eu-repo/semantics/openAccess