Data/hora: 04/06/2024 02:45:39

Provedor de dados: | 56
País: | Brazil
Título: | Atherogenic lipid profile of Brazilian near-term newborns
Autores: | Pardo,I.M.C.G.; Geloneze,B.; Tambascia,M.A.; Barros-Filho,A.A.
Data: | 2005-05-01
Ano: | 2005
Palavras-chave: | Lipids; Apolipoproteins; Cholesterol; Cord blood; Cardiovascular disease; Newborns.
Resumo: | Cardiovascular disease is the primary cause of death in Brazil. Recent studies have shown that low birth weight and preterm birth are linked to a higher prevalence of cardiovascular disease. The aim of the present study was to compare the levels of lipids and apolipoproteins and atherogenic indexes between term and near-term newborn infants. A sample of umbilical cord blood was obtained from 135 newborns (66 males) divided into two groups: 25 near-term neonates (35-36.6 weeks of gestational age) and 110 term neonates (37-42 weeks of gestational age). The total cholesterol concentrations were higher in the near-term neonates than in the term group (94.04 ± 8.02 vs 70.42 ± 1.63 mg/dl, P &lt; 0.01), due to an increase in the LDL-cholesterol fraction in the near-term group (57.76 ± 6.39 vs 34.38 ± 1.29 mg/dl, P &lt; 0.001). The atherogenic indexes (total cholesterol/HDL-cholesterol, LDL-cholesterol/HDL-cholesterol and apolipoprotein B/apolipoprotein A-I) were higher in the near-term group (P &lt; 0.001, P &lt; 0.001, and P &lt; 0.05, respectively). The gestational age of the newborns was inversely correlated with total cholesterol and LDL-cholesterol, and also with the total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol indexes. These findings demonstrate that the lipid profile is worse in the group of near-term neonates compared with the term group. Future studies are needed to determine if this atherogenic profile in near-term neonates can affect body metabolism, increasing the risk for cardiovascular diseases in adult life.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2005000500013
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.38 n.5 2005
Fonte: | info:eu-repo/semantics/openAccess