Data/hora: 02/06/2024 08:54:52

Provedor de dados: | 56
País: | Brazil
Título: | The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics
Autores: | Licinio,J.; Frost,P.
Data: | 2000-10-01
Ano: | 2000
Palavras-chave: | Central nervous system; Cytokines; Immune system; Neuroendocrine regulation; Fever; Food intake.
Resumo: | Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In the 80's and 90's our group and others discovered that the genes encoding various cytokines and their receptors are expressed in vascular, glial, and neuronal structures of the adult brain. Most cytokines act through cell surface receptors that have one transmembrane domain and which transduce a signal through the JAK/STAT pathway. Of particular physiological and pathophysiological relevance is the fact that cytokines are potent regulators of hypothalamic neuropeptidergic systems that maintain neuroendocrine homeostasis and which regulate the body's response to stress. The mechanisms by which cytokine signaling affects the function of stress-related neuroendocrine systems are reviewed in this article.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000003
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2000001000003
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.33 n.10 2000
Fonte: | info:eu-repo/semantics/openAccess