Data/hora: 02/06/2024 12:54:24

Provedor de dados: | Brazilian Journal of Medical and Biological Research
País: | Brazil
Título: | Application of various antioxidants in the treatment of influenza
Autores: | Dolganova,A.; Sharonov,B.P.
Data: | 1997-11-01
Ano: | 1997
Palavras-chave: | Free radicals; Influenza; Antioxidant; Desferrioxamine; Superoxide dismutase; Allopurinol.
Resumo: | We determined the effect of the antioxidants superoxide dismutase, desferrioxamine and allopurinol on the survival of male CBA mice infected intranasally with 2-5 LD50 lung influenza virus A/Aichi/2/68. Survival for at least 20 days was observed for 45% of the mice that received 1000 U/day superoxide dismutase prepared from red blood cells on days 5, 6, 7 and 8 after infection, and 75% survival was observed for mice that received the same dose on days 4, 5, 6, 7 and 8. Desferrioxamine, 25 mg/kg per day and 100 mg/kg per day injected subcutaneously, resulted in survival rates of 5 and 0%, respectively, compared to 10% survival observed for saline-injected controls. Allopurinol at doses of 5 to 50 mg/kg per day had no effect on mouse survival. These data demonstrate the efficacy of superoxide dismutase for the protection of mice against hemorrhagic lung edema. The ineffectiveness of allopurinol suggests that the xanthine oxidase system does not play a major role in hemorrhage or lung edema and that caution is necessary when desferrioxamine is administered during an acute inflammatory process accompanied by erythrocyte lysis
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100012
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X1997001100012
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.30 n.11 1997
Fonte: | info:eu-repo/semantics/openAccess